‘Nonsensical’ Limits on Supportive Drugs Complicate Cancer Care

November 13, 2024

A young woman with breast cancer was experiencing such intense hot flashes from her triplet chemotherapy regimen, AC-T, that she begged to stop treatment.

Her oncologist, Ramy Sedhom, MD, suggested she take oxybutynin, an inexpensive drug for overactive bladder that has been shown to help reduce hot flashes. But her insurer refused to pay for the drug, even after Sedhom had several peer-to-peer discussions with the insurer in which he emphasized the effectiveness and low cost of the medication.

Frustrated, Sedhom, a medical oncologist at the University of Pennsylvania Perelman School of Medicine in Philadelphia, suggested the patient buy oxybutynin directly from CostPlus Drug Company. The site sells the medication for $6.50 for 30 pills.

The oxybutynin was a game changer. It curbed the patient’s hot flashes and helped her remain on the chemotherapy regimen.

But the headache the patient experienced was “unfair,” said Sedhom, also medical director of oncology and palliative care at Penn Medicine Princeton Health.

Insurers and pharmacy benefit managers (PBMs) have traditionally used processes to evaluate the necessity of medical treatments and services on an individual patient basis — a practice called utilization management. But utilization management techniques, which include prior authorization, can also delay or flat out deny essential care for patients. Even if treatments are eventually approved, patients still may be on the hook for a large portion, sometimes all, of the cost.

Read more at Medscape Medical News.

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Anthem Reverses Course on Anesthesia Time Limits

December 6, 2024

The nation’s second-largest health insurer, Anthem, has rescinded a controversial policy to pay for anesthesia only up to a certain time limit that sparked outrage among anesthesiology professionals and state officials.

The company announced November 1 it would deny claims for anesthesia that exceeded time limits set by the insurer, with exceptions for maternity care and patients younger than 22 years. The policy was set to begin February 1 for commercial plans and Medicaid managed care plans in Colorado, Connecticut, New York, and Missouri.

But after behind-the-scenes lobbying by anesthesiology groups and intense public criticism as news spread online this week, Anthem said Thursday it would no longer pursue the policy. The insurer serves about 46 million enrollees in its health plans and its parent company, Elevance Health, reported $170 billion in revenues in 2023.

“There has been significant widespread misinformation about an update to our anesthesia policy,” Elevance Health spokeswoman Janey Kiryluik told Medscape Medical News. “As a result, we have decided to not proceed with this policy change.” 

The reversal comes several weeks after officials from the American Society of Anesthesiologists (ASA) met briefly with Anthem.

Read more at Medscape Medical News.

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Gun Violence Researchers Are Making Up for 20 Years of Lost Time

August 4, 2021

Depending on who you ask, the end of a 2-decade dry spell in federal funding for gun violence research is a windfall or a pittance. Either way, experts in the field say that renewed funding is especially urgent now, as the US heads into a second year of record firearm-related violence.

By late July, the Gun Violence Archive reported 25 370 US firearm deaths in 2021, putting the year on track to surpass last year’s 43 559 deaths. US Centers for Disease Control and Prevention (CDC) data showed that 39 707 people lost their lives to gun violence in 2019. It was the third consecutive year in which US gun violence deaths approached 40 000 and the end of a decade in which the death rate from gun violence increased by 17%, from 10.1 to 11.9 deaths per 100 000 population. The rate has remained above 11 per 100 000 population since 2015.

Although the CDC gathers firearm mortality data, its gun violence research had largely been dormant since 1996 when the Dickey Amendment prohibited the agency from using its injury prevention funding “to advocate or promote gun control.” The amendment technically didn’t prohibit gun violence research, but the chill was numbing.

In 2019, however, Congress authorized $25 million in spending on gun violence research, to be split evenly between the CDC and the National Institutes of Health (NIH). Although the amount is nearly 10 times greater than the $2.6 million that the CDC was spending on gun violence prevention studies when the Dickey Amendment took effect, a leading expert said the field is still woefully underfunded.

Read more at JAMA.

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US Supreme Court unlikely to approve assisted suicide

January 18, 1997

Should physicians be allowed to give terminally ill patients lethal doses of medication? This question, more frequently on the minds of people in the US thanks to Jack Kevorkian, came before the Supreme Court on Jan 8. The nine Justices considered whether bans on physician-assisted suicide in New York and Washington states infringed on personal liberty. However, the Court was less concerned with Constitutional questions than whether their affirmation of a right to assisted suicide would lead down a “slippery slope” to euthanasia of the disabled.

Read more at The Lancet.

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How an Indigenous Weaver’s Mastery of Color Infuses Her Tapestries With a Life Force

October 16, 2024

A red tapestry is edged with indigo at the top and bottom and features an undulating line of the same color across the top quarter. The work is a flat rectangle of wool, but the vibrancy of the colors makes it seem almost alive.

The piece, Monumental Edge 2, is one of 48 tapestries by DY Begay on display in “Sublime Light,” an exhibition at the Smithsonian’s National Museum of the American Indian that runs through July 2025.

While Begay, who is Diné (or Navajo), has exhibited her work often in the American Southwest, she is perhaps not as familiar elsewhere. The National Museum of the American Indian aims to change that, for Begay and others. The museum is well-positioned to “call attention to incredibly talented artists that are well-known in the Native American art world in Santa Fe but are not really all that well-known in the mainstream art world,” says associate curator Cécile R. Ganteaume.

Read more here at Smithsonian.com.

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How Golden Peacocks on a Dining Room Wall Destroyed a Longstanding Friendship in Victorian Society

July 19, 2024

When James McNeill Whistler put the final, defiant flourishes upon two golden peacocks on art collector Frederick Leyland’s dining room wall, it was an act that would lead to the end of a long and lucrative friendship, and the rupture of Whistler’s success as a painter.

The story of that dining room—called the Peacock Room and considered one of Whistler’s masterpieces—has long been rife with mythology about the drama surrounding its creation and denouement. The room was the subject of much gossip among Victorian society at the time, and its story has been frequently layered-upon and exaggerated over the 147 years since its completion.

Read more here at Smithsonian.com.

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Psychologists and Psychotropic Prescribing: An Old Debate Heats Up

December 13, 2024

Earlier this year, Utah became the seventh state to allow psychologists with the proper training to prescribe psychotropic medications, giving supporters reason to hope that more states might support expanding this scope of practice.

However, the American Psychiatric Association — and some psychologists — oppose granting psychologists this privilege, arguing that the training offered is insufficient and could jeopardize patient safety.

The controversy over whether psychologists should be allowed to prescribe is as old as the so-called RxP movement itself, which began in the early 1990s.

Psychologists have not rushed to become licensed prescribers. After three decades, an estimated 226 psychologists — representing just 0.14% of all those licensed in the United States — have been authorized to prescribe in the six states and one territory where it has been legalized, according to a just-published study in Clinical Psychology: Science and Practice.

Read more here at Medscape Medical News.

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Should the FDA Reconsider Antidepressant Boxed Warnings?

December 23, 2024

For almost two decades, antidepressants have carried boxed warnings linking the medications to an increased risk for suicidal thoughts and behaviors in young people. Paradoxically, and for almost as long, evidence suggests these warnings may have led to fewer depression diagnoses, reduced prescriptions, and, ultimately, higher suicide rates.

With mounting evidence of these negative unintended consequences, some clinicians and researchers are urging the US Food and Drug Administration (FDA) to consider revising — or even eliminating — boxed warnings on these medications.

Read more here at Medscape Medical News.

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Ask Smithsonian: Why Do We Kiss?

Love snuggling up to a sweetie and smooching? That’s romantic, but—spoiler alert—kissing can be a disgusting and dangerous activity.  While kissing, couples exchange 9 milliliters of water, 0.7 milligrams of protein, 0.18 mg of organic compounds, 0.71 mg of fats, and 0.45 mg of sodium chloride, along with 10 million to 1 billion bacteria, according to one accounting. Many pathological organisms can be transmitted through mouth-to-mouth contact, including those that cause colds and other respiratory viruses, herpes simplex, tuberculosis, syphilis and strep.

Read more.

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What Is Bertsolaritza And Who Are The Basque Poets Who Know It

Part poetry-slam, part hip-hop freestyling, part a cappella singing and 100 percent improvisational, the tradition of bertsolaritza has become a cultural signifier for the Basque diaspora.

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Cancer Moonshot Effort Unveils Dozens of Initiatives to Speed Research

WASHINGTON, DC — US federal officials have unveiled a dozen new initiatives designed to accelerate cancer research, speed new therapies to patients, foster data sharing, and simplify participation in clinical trials, all part of the formal liftoff of the Cancer Moonshot program. The Moonshot program, headed by Vice President Joe Biden, aims to “end cancer once and for all.”  The new initiatives were announced in conjunction with Moonshot summits being held on June 29 in Washington, DC, and at 260 locations in all 50 states, Puerto Rico, and Guam…..”I firmly believe we can do in the next 5 years what would ordinarily take 10,” Vice President Biden said at the Washington, DC, summit. Read more…

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Ask Smithsonian: How Do Spiders Make Their Webs?

Spiders are skillful engineers, gifted with amazing planning skills and a material that allows them to precisely design rigorous and functional webs.

The material—spider silk—has chemical properties that make it lustrous, strong and light. It’s stronger than steel and has impressive tensile strength, meaning it can be stretched a lot before it snaps. Scientists have been trying for decades to decode exactly what gives the silk both strength and elasticity, but so far they have found only clues.

Any individual spider can make up to seven different types of silk, but most generally make four to five kinds, says Jonathan Coddington, director of the Global Genome Initiative and senior scientist at the Smithsonian’s National Museum of Natural History.
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Artist Chakaia Booker Gives Tires a Powerful Retread

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The first thing you notice is the smell. It’s a bit industrial, but also, maybe a tiny bit pleasant.

The odor encapsulates Chakaia Booker’s latest massive sculptural work, displayed as part of the “Wonder” exhibition at the recently reopened Renwick Gallery of the Smithsonian American Art Museum. The piece, like its smell, might be at home on a factory floor. It is a bit dark and threatening. But, there’s also something inviting about both the odor and the artwork. It draws you into the room, to stroll between the sculpture’s three undulating walls, and to touch their seemingly animated shreds.

From a distance, the sculpture recalls a school of swimming fish, or an orderly grouping of fall leaves. But these forms are constructed of tires that have been shredded and diced and sliced and then wrapped around stainless steel.

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Califf Breezes Through Nomination Hearing for FDA Chief

WASHINGTON — Most members of a Senate committee had few reservations yesterday about Robert Califf’s qualifications to be the next commissioner of the US Food and Drug Administration (FDA).

“You come here today with impressive qualifications,” said Senate Health, Education, Labor and Pensions Committee (HELP) Chairman Lamar Alexander (R-Tenn), who clearly was a fan, as were many other Republican members of the panel.

Questions about Dr Califf’s ties to the pharmaceutical industry, however, have dogged him since President Obama nominated him in September to lead the FDA. Read More

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